DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar Homeostasis in Vascular Malformations
نویسندگان
چکیده
منابع مشابه
Multivalent Electrostatic Interactions and Autoinhibition Underlie Phase Separation of Npm1 with R-rich Nucleolar Protein Surf6
The nucleolus, the largest membrane-less organelle, is critical to cellular functioning as the site of ribosome biogenesis and as a fundamental cell stress sensor. It has previously been shown that the nucleolus assembles via liquid-liquid phase separation of its components from the surrounding nucleoplasm. Here, we show that two abundant nucleolar proteins often upregulated in certain cancers,...
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The onset and duration of sleep are thought to be primarily under the control of a homeostatic mechanism affected by previous periods of wake and sleep and a circadian timing mechanism that partitions wake and sleep into different portions of the day and night. The mouse Clock mutation induces pronounced changes in overall circadian organization. We sought to determine whether this genetic disr...
متن کاملvascular malformations in the maxillofacial region
congenital vascular lesions occur most often in children. parents of these children take them to maxillofacial surgeons directly or during the treatment of other complications such as infection or jaw bone disorders. various terms now used are unable to describe the pathogenesis and mechanism of the effect of vascular lesions on growth and development of facial bone. term of hemangioma is used...
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OBJECTIVE The matricellular protein NOV/CCN3, is implicated in osteoarthritis (OA) and targeted mutation of NOV in mice (Nov(del3)) leads to joint abnormalities. This investigation tested whether NOV is required for joint homeostasis and if its disruption causes joint degeneration. METHOD NOV expression in the adult mouse joint was characterized by immunohistochemistry. A detailed comparison ...
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Spo13 is a key meiosis-specific regulator required for centromere cohesion and coorientation, and for progression through two nuclear divisions. We previously reported that it causes a G2/M arrest and may delay the transition from late anaphase to G1, when overexpressed in mitosis. Yet its mechanism of action has remained elusive. Here we show that Spo13, which is phosphorylated and stabilized ...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2023
ISSN: ['1449-2288']
DOI: https://doi.org/10.7150/ijbs.84097